Angiotensin AT 1 Receptor Inhibition

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Abstract
Background We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)–receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. Methods and Results Six weeks after surgery, rats with ascending aortic stenosis were randomized to receive either the AT1-receptor blocker BMS-186295 50 mg·kg−1·d−1 (n=49), amlodipine 2.5 mg·kg−1·d−1 (n=48) as a positive control for systemic vasodilation, or no drug (n=48) and compared with sham-operated rats (n=39). Drug treatment was continued for 15 weeks. Left ventricular ACE mRNA levels were measured by ribonuclease protection assay. The left ventricular/body weight ratio was increased 43% in hearts from rats with untreated left ventricular hypertrophy (LVH) versus control hearts (P<.05). However, there was no difference in either the left ventricular/body weight ratio (2.78±0.08 versus 2.81±0.20 mg/g; P=NS) or myocyte cros...

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