Thermographische Untersuchungen zum Wirkungsmechanismus von Timolol

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Abstract
Distribution of local temperature in the anterior segment was investigated after topical administration of timolol 0.5% using IR thermography. Patients (80) were included in this study; the untreated eye was used as a control. Within 30 min of timolol instillation a decrease in local temperature of up to 3.degree. C was observed in 44% of the cases; in 32% no change and in the remaining 24% a small increase of up to 1.degree. C occurred. In 10 other patients thermography and applanation tonometry were carried out simultaneously over a period of 4 h following topical administration of timolol; in this preliminary series a maximal local temperature decrease occurred after 90 min, i.e., prior to the maximal effect on intraocular pressure. Topical administration of timolol reduces the ciliary blood flow.