Neuroendocrine Carcinoma of the Ampulla of Vater: A Case of Absence of Somatostatin in a Vasoactive Intestinal Polypeptide-, Bombesin-, and Cholecystokinin-Producing Tumor
Open Access
- 1 January 1991
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 95 (1) , 51-54
- https://doi.org/10.1093/ajcp/95.1.51
Abstract
A 31-year-old patient with a clinical picture of obstructive jaundice had surgical treatment, and a primary carcinoid of the ampulla of Vater (VA) was found. The tumor was studied with light microscopy, immunohistochemistry, and electron microscopy. The neoplasm had histopathologic and cytopathologic features similar to those encountered in typical neuroendocrine neoplasms. It is interesting that immunohistochemical techniques disclosed the presence of vasointestinal polypeptide, cholecystokinin, and bombesin; however, unlike most neuroendocrine neoplasms arising in VA, no somatostatin-immunoreactive cells were found.Keywords
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