INHIBITION OF ANGIOTENSIN III ACTION BY DES-ASP1-,ILEU8-ANGIOTENSIN II IN MAN
- 1 February 1978
- journal article
- research article
- Published by Bioscientifica in Acta Endocrinologica
- Vol. 87 (2) , 359-366
- https://doi.org/10.1530/acta.0.0870359
Abstract
In 5 normal men i.v. infusion of 600 ng/kg per min of des-asp1-,ileu8-angiotensin II (AIIIA) inhibited a rise in blood pressure as well as increase in plasma aldosterone caused by an i.v. infusion of 20 or 100 ng/kg per min of des-asp1-angiotensin II (angiotensin III, AIII). This result and a previous study on simultaneous infusions of 600 ng/kg per min of AIIIA and 20 ng/kg per min of angiotensin II (AII) in the same 5 normal men demonstrate that this dose of AIIIA antagonizes AIII and AII on the adrenal cortex as well as peripheral arterioles. Also, AIIIA has the same degree of inhibitory effect on the aldosterone-stimulating action of AIII and on that of AII in man.This publication has 5 references indexed in Scilit:
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