β2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions
- 1 January 1994
- journal article
- research article
- Published by Wiley in Journal of Clinical Laboratory Analysis
- Vol. 8 (5) , 255-259
- https://doi.org/10.1002/jcla.1860080502
Abstract
We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme-linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2-glycoprotein I (β2-GPI). Sixteen patients (7.5%) were positive for β2-GPI-dependent aCL. Though β2-GPI appeared to enhance the binding of aCL, β2-GPI-independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2-GPI-dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester.Keywords
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