Cardiovascular and autonomic effects of fenfluramine hydrochloride
- 1 April 1965
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 17 (4) , 222-226
- https://doi.org/10.1111/j.2042-7158.1965.tb07648.x
Abstract
Fenfluramine hydrochloride (N-ethyl-α-methyl-3-trifluoromethylphenethylamine hydrochloride; AHR-965) administered orally or intravenously to anaesthetised or unanaesthetised dogs, caused a predominant rise in arterial blood pressure, tachycardia, an increase in myocardial contractile force and cardiac output, and an enhanced total peripheral resistance. Fenfluramine was qualitatively like dexamphetamine in its cardiovascular effects; however dexamphetamine was 10 to 20 times more potent as a pressor agent.Keywords
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