The isolation of prostaglandin E from pig nasal mucosa

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Abstract
Prostaglandins of the E series (PGE) have been shown to be potent nasal vasoconstrictors but were not previously isolated from the nasal mucosa. The isolation of a biologically active substance with properties similar to PGE were reported from pig nasal mucosa. The substance was identified as PGE on the following criteria: isolation procedure demonstrated the presence of a biologically active polar acidic lipid; caused contractions of the isolated rat stoamch fundic strip similar to PGE2; caused a prolonged nasal vasoconstriction similar to PGE2 and travelled on thin layer chromatogram with PGE. The PGE found in the nasal mucosa may have a role in the regulation of mucosal blood flow in normal and pathological conditions.