HLA-DR effects in a large German IDDM dataset
- 1 January 1986
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 3 (S1) , 323-328
- https://doi.org/10.1002/gepi.1370030749
Abstract
DR4 and DR3 are in strongest linkage disequilibrium with IDDM susceptibility genes, and DR1 demonstrates a lesser degree of positive disequilibrium. DR3/DR4 heterozygotes have the highest risk. The DR1 increase occurs almost exclusively in DR4/DR1 heterozygotes, suggesting that DR1 may be in disequilibrium with the same susceptibility gene as DR3. Homozygotes for DR4 and especially DR3 have a higher risk than heterozygotes of either with DRX. GLO-2 is increased in diabetic haplotypes carrying DR4, DR3 or DR1.Keywords
This publication has 2 references indexed in Scilit:
- Extended major histocompatibility complex haplotypes in type I diabetes mellitus.Journal of Clinical Investigation, 1984
- Population Analysis on the Basis of Deduced Haplotypes from Random FamiliesPublished by Springer Nature ,1984