Principles of Detection in Single-Column lon Chromatography

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Abstract
At one time or another virtually every type of detector has been used for ion chromatography. But, in order for these detectors to operate, certain fundamental criteria of the separation column (and the separation mechanism), eluant, and sample must be met. If an ion-exchange process is used to separate the ions, then detection of the ions is based on the difference in detector response of the sample and eluant ions. This phenomenon, which is universal for all detector, is based on the fact that the sample ion replaces the eluant ion during the elution process. In ion-exclusion chromatography, the elution of a sample species involves an addition of the sample to the eluant. Thus equations describing this behaviour are quite different to ion-exchange ion chromatography.