Host-Parasite Relationships of Fasciola hepatica in the White Mouse. VIII. Successful Vaccination with Culture Incubate Antigens and Antigens from Sonic Disruption of Immature Worms

Publisher Website
Google Scholar
Abstract
Mice were successfully vaccinated using culture incubate and sonicate antigens from 16 day old flukes. Various injection schedules using the culture incubate antigen decreased challenge worm counts by 54-86%. The best results were achieved when the culture incubate was injected at 12 and 24 h incubation. Host mortality in the natural immunity controls ranged from 33-42%, and in the vaccinated animals from 12.5-25%. Functional antigens were present by 12 h of incubation. A single immunizing injection with the sonicate antigen decreased challenge worm counts by 86%. Two immunizing injections with this antigen decreased challenge worm counts by 82%, but the pathologic process in the liver was more severe than in animals that received a single injection.

This publication has 0 references indexed in Scilit: