Autoimmune Responses in Rats Observed by Hemagglutination of Gas-Treated Erythrocyte Antigens With Rat Antiserums

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Abstract
Using classical immunological hemagglutination tests, if has been found that autoimmune responses can be elicited in Sprague-Dawley and Charles River rats after a single intraperitoneal injection of their own gas-treated erythrocytes. Controls included compressed-air treated cells, saline-treated cells, normal cells, and gassed saline-treated cells. The following gases were found to affect the antigenic potential of rat erythrocytes to the extent that the animals produced antibodies against these cells: octafluorocyclobutane (Freon C 318), oxygen, carbon dioxide, butane, methane, argon, propane, and ethane. Only nitrogen and compressed air had no effect. It cannot be concluded from this work that similar reactions occur in vivo, yet future investigations should include in vivo experiments both on a short-range and long-range basis.

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