A reference material for traceability of aspartate aminotransferase (AST) results
- 1 January 2005
- journal article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 43 (5) , 549-53
- https://doi.org/10.1515/cclm.2005.095
Abstract
Standardization of aspartate aminotransferase (AST) determination is highly desirable for inter-laboratory comparison. Serum AST mean values for 20 patients suffering from viral hepatitis showed an inter-laboratory (n=13) variation of 9.4%. Part of this variation was due to two laboratories using procedures without pyridoxal-5′-phosphate. A traceable AST value was assigned to an enzyme calibrator (EC) through the appropriate International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) primary reference procedure. The EC was commutable for seven routine methods. Common calibration using the EC reduced the inter-laboratory coefficient of variation (CV=5.9%Keywords
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