Proteolytic cleavage of the repressor (BlaI) of β-lactamase synthesis in Staphylococcus aureus
- 15 September 1999
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 178 (2) , 271-275
- https://doi.org/10.1016/s0378-1097(99)00366-3
Abstract
The proteolytic cleavage of BlaI was shown to correlate with β-lactamase synthesis in Staphylococcus aureus . BlaI was found to be autoregulatory when expressed from the blaZ promoter. Insertion of a 10-bp linker into the Sna BI site of blaRI resulted in constitutive synthesis of β-lactamase.Keywords
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