A MODEL OF IMMUNE COMPLEX-MEDIATED PLEUROPULMONARY INJURY - EVIDENCE OF DEPOSITION OF CIRCULATING IMMUNE-COMPLEXES IN THE LUNG

  • 1 January 1980
    • journal article
    • research article
    • Vol. 100  (1) , 115-+
Abstract
Severe acute, diffuse lung inflammation was induced in rabbits immunized to bovine serum albumin (BSA) and subsequently challenged with BSA intrapleurally. Evidence suggesting involvement of circulating immune complexes in the pathogenesis of lung injury in these rabbits include positive lung immunofluorescence, a fall in serum hemolytic complement, diffuse bilateral involvement despite unilateral antigen challenge and absence of these findings in control rabbits.