Oral Treatment of Subacute Bacterial Endocarditis with Phenoxymethyl Penicillin (Penicillin V)

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Abstract
THE current treatment of subacute bacterial endocarditis requires the intramuscular administration of large amounts of penicillin. Although this route is generally well tolerated, pain and inflammation at local sites of injection can become a significant problem in the management of certain patients. Because of low and unpredictable serum levels attained after oral administration of penicillin G, effective oral therapy has not previously been available.Recent studies on phenoxymethyl penicillin (penicillin V) have suggested that this agent may represent a better means of oral administration. This compound is stable and relatively insoluble at pH ranges below 3.0. It is readily converted . . .