Effect of acute and chronic 17β-estradiol treatment on serotonin and 5-hydroxyindole acetic acid content of discrete brain nuclei of ovariectomized rat
- 1 June 1983
- journal article
- Published by Springer Nature in Experimental Brain Research
- Vol. 51 (1) , 73-76
- https://doi.org/10.1007/bf00236804
Abstract
Increased serotonin content of the dorsal raphe nucleus and of the substantia nigra were seen following acute (12 h or 24 h) administration of 17β-estradiol to ovariectomized rats. No changes were seen in numerous other nuclei of forebrain or hindbrain, and no changes occurred during chronic (1 month) estradiol administration. Changes in the concentration of the major serotonin metabolite, 5-hydroxyindole acetic acid, paralleled those of serotonin. These results show that, under precisely defined conditions and in specific locations only, estradiol can modulate serotonergic neuronal systems.Keywords
This publication has 23 references indexed in Scilit:
- Isolated removal of hypothalamic or other brain nuclei of the ratPublished by Elsevier ,2003
- Effects of ovarian steroids on serotonin metabolism within grossly dissected and microdissected brain regions of the ovariectomized ratBrain Research Bulletin, 1981
- Estradiol treatment decreases type A and increases type B monoamine oxidase in specific brain stem areas and cerebellum of ovariectomized ratsBrain Research, 1981
- Serotonin receptor concentration during the estrous cycle of the ratBrain Research, 1980
- The Brain as a Target for Steroid Hormone ActionAnnual Review of Neuroscience, 1979
- The effect of ovarian steroids on the accumulation of3H-labelled monoamines by hypothalamic tissuein vitroBrain Research, 1974
- Serotonin and Central Nervous System FunctionAnnual Review of Pharmacology, 1973
- Activation of Lordotic Responding in Female Rats by Suppression of Serotonergic ActivityScience, 1973
- Changes in brain monoamine concentrations during the oestrous cycle in the mouse: possible pharmacological implicationsJournal of Pharmacy and Pharmacology, 1971
- Serotonin synthesis inhibition and estrous behavior in female ratsLife Sciences, 1970