3-Hydroxykynurenine, 3-Hydroxyanthranilic Acid, and o-Aminophenol Inhibit Leucine-Stimulated Insulin Release from Rat Pancreatic Islets
- 1 February 1985
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 178 (2) , 275-278
- https://doi.org/10.3181/00379727-178-42010
Abstract
Individual islets were isolated from rat pancreas to study the effects of tryptophan and its metabolites on leucine-stimulated release of insulin. 3-Hydroxykynurenine, 3-hydroxyanthranilic acid and o-aminophenol were inhibitors at concentrations below 10 mM whereas tryptophan, kynurenine, kynurenic acid, xanthurenic acid and anthranilic acid were ineffective inhibitors at concentrations up to 10 mM. A structure-activity analysis of these metabolites demonstrated that vicinal aromatic hydroxy and amino groups with their concomitant electron donating properties are required for inhibition of insulin release. Inhibition of islet insulin release by the 3 kynurenine metabolites may be involved in the depressed insulin levels found in vitamin B6-deficient rats.This publication has 1 reference indexed in Scilit:
- Effect of Lithium on Pancreatic Islet Insulin Release*Endocrinology, 1978