CL regression in the pseudopregnant rabbit and the effects of treatment with prostaglandin F-2 and arachidonic acid

Publisher Website
Google Scholar
Abstract
During pseudopregnancy in the rabbit, plasma progesterone levels in the posterior vena cava fell rapidly from maximal concentrations of 9.8 .+-. 0.7 (s.e.m. [standard error of the mean]) ng/ml on day 13 of pseudopregnancy to 2.0 .+-. 0.6 ng/ml on day 15. There was no significant increase in PG[prostaglandin]F levels at this time, although administration of indomethacin to a similar group of does delayed functional regression for over 7 days. Injection [s.c.] of 1 mg PGF2.alpha. or 35 mg arachidonic acid on day 9 of pseudopregnancy resulted in loss of luteal function as plasma progesterone levels fell significantly from about 6 to < 1 ng/ml within 24 h. These findings indicate that the uterine factor responsible for luteolysis in the pseudopregnant rabbit may not be released in the form of PGF2.alpha.