Recurrent Cutaneous Anaplastic Large Cell (CD30+) Lymphoma Associated With Epstein-Barr Virus

1 August 1992

journal article
case report
Published by Wolters Kluwer Health in The American Journal of Surgical Pathology

Vol. 16 (8) , 796-801
https://doi.org/10.1097/00000478-199208000-00009

Abstract

CD30-positive large cell cutaneous T-cell lymphomas are known to be associated with the human T-cell leukemia/lymphoma virus type I. We present a case of anaplastic large cell lymphoma that recurred three times during 9 years at different sites. Molecular studies [polymerase chain reaction (PCR), in situ hybridization] showed Epstein-Barr virus (EBV) genome in biopsy samples of this first reported case of EBV-associated cutaneous anaplastic large cell lymphoma. This case was human T-lymphotropic virus-1 and -2 negative by PCR. The results add some evidence to the hypothesis that EBV may be a factor in the pathogenesis of cutaneous lymphoproliferative lesions.

Keywords

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