MONITORING AND RISK ASSESSMENT BY MEANS OF ALKYL-GROUPS IN HEMOGLOBIN IN PERSONS OCCUPATIONALLY EXPOSED TO ETHYLENE-OXIDE
- 1 January 1978
- journal article
- research article
- Vol. 2 (2) , 427-442
Abstract
In persons occupationally exposed to ethylene oxide, i.e., under the conditions described by Dunkelberg and Hartmetz, the degree of alkylation in histidine of Hb was determined. Quantitative determination of N-3-(2-hydroxyethyl)histidine by mass fragmentography and by ion-exchange amino acid analysis gave consistent results. Data are in agreement with the fast elimination from tissues (.lambda. = 4.6 h-1, i.e., biological half-life about 9 min) found in the mouse. At the respiration rate of light work, an exposure dose of 1 ppm/h results in a tissue dose that involves an estimated risk of 1x101 mrad-equivalents of stochastic effects such as mutation and cancer with a genetic mechanism.This publication has 4 references indexed in Scilit:
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- Chronic Toxicity or Ethylene OxideArchives of environmental health, 1964