The effects of intragastric injections of various substances on subsequent bar-pressing.

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Abstract
Four experiments are reported, all dealing with the effects of intragastric injection (by stomach tube) on hunger, as measured by the subsequent rate of bar-pressing for a food reward. The results indicated that a fortified milk had a profoundly depressing effect on response rate, as did a 1[image] sucrose solution. Bulk alone (Kaolin) had no effect, nor did sugar alone (isotonic glucose). A 1[image] solution of sorbitol had the same effect as a 1[image] solution of glucose. A 1[image] solution of glycerol had an intermediate effect. The results are tentatively interpreted to indicate that a mechanical distention and a humoral change must act in conjunction to reduce hunger.

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