Accentuation of Essential Fatty Acid Deficiency by Dietary Tri-o-cresyl Phosphate

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Abstract
Dietary addition of tri-o-cresyl phosphate (TCP) to an EFA-free 18% casein diet accentuated the deficiency and decreased the time of onset of dermal lesions in rats. Dietary intake of TCP caused increases in dermal scores and eicosatrienoic acid (E) and decreases in arachidonic acid (A) in liver lipids of both the deficient and the control groups. In carcass lipid, however, dietary additions of TCP caused decreases in both eicosatrienoic and arachidonic acids of the deficient groups. TCP depressed growth of the deficient and control rats; however, the depression was greatest in the deficient animals. Dietary TCP accentuated the decrease in oxidative phosphorylation noted in an uncomplicated EFA deficiency. Liver cholesterol increased in EFA-deficient rats, and this was accentuated by dietary TCP. Values for total lipids of liver, heart and carcass are also reported.
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