Effect of an Acute Dose of Ethanol on Lipid Peroxidation and on the Activity of Microsomal Glutathione S‐Transferase in Rat Liver
- 1 August 1983
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 53 (2) , 135-140
- https://doi.org/10.1111/j.1600-0773.1983.tb01881.x
Abstract
Acute ethanol administration (1.5 g/kg) to fasted rats resulted in a small but significant increase in the content of conjugated dienes in the microsomal fraction of liver. Treatment with 4-methylpyrazole prior to ethanol ingestion was able to reduce the ethanol-induced lipid peroxide formation (measured as conjugated dienes). No depletion of glutathione occurred within the first 2 h following ethanol administration by which time lipid peroxide formation is well established. The ethanol-induced inhibition of N-ethylmaleimide-stimulated microsomal glutathione S-transferase activity correlates positively to the concentration of conjugated dienes in the microsomal fraction of liver.Keywords
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