Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine
Open Access
- 1 July 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 41 (7) , 1033-1037
- https://doi.org/10.1093/clinchem/41.7.1033
Abstract
Because high plasma concentrations of homocysteine constitute an enhanced risk for premature coronary heart disease, it is necessary to establish a reference range for normal concentrations of plasma homocysteine. The frequency distribution of plasma homocysteine concentrations tails to the right, and the nonparametric approach is unsatisfactory for defining a normal plasma homocysteine reference range. By using subjects' responses to appropriate vitamin supplementation, we developed a mathematical prediction model to calculate the plasma homocysteine concentration that could be expected for each individual treated with a vitamin supplement. With this model, we can predict that plasma homocysteine concentrations will approach a normal frequency distribution with a 95% reference range (mean +/- 2 SD) of 4.9-11.7 mumol/L, provided the vitamin status of the study population is improved.Keywords
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