Complexes between Nucleotide Base and Amino Acid. I. Crystal Structure of Cytosine: N-Formylglycine
- 1 March 1975
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 48 (3) , 848-852
- https://doi.org/10.1246/bcsj.48.848
Abstract
Cytosine: N-formylglycine complex crystallizes in the space group Pna21 with cell dimensions of a=8.444(2), b=21.169(5), and c=5.120(1) Å. The structure was solved by the trial-and-error method on the basis of a Patterson map. A full-matrix least-squares refinement led to an R value of 0.035. The difference map revealed the protonation of cytosine by the carboxyl group of N-acylamino acid and the involvement of ionic interaction in complex formation. This mode is the same as proposed for cytosine: N-benzoylglycine complex in spite of different molecular environment. Such arrangement of cytosine and ionized carboxyl group of amino acid may suggest a mutual recognition scheme between nucleic acid and protein.This publication has 11 references indexed in Scilit:
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