The role of molecular oxygen in clavulanic acid biosynthesis: evidence for a bacterial oxidative deamination

1 January 1988

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 18,p. 1234-1236
https://doi.org/10.1039/c39880001234

Abstract

Growth of cultures of Streptomyces clavuligerus(ATCC 27064) in an ¹⁸O₂-containing atmosphere resulted in efficient and equal incorporations of molecular oxygen into the oxazolidine ring and the allylic hydroxy group of clavulanic acid.

Keywords

MOLECULAR OXYGEN
CLAVULANIC
CONTAINING ATMOSPHERE
EQUAL INCORPORATIONS
HYDROXY GROUP
18O2 CONTAINING
ALLYLIC HYDROXY
ATMOSPHERE RESULTED
DEAMINATION GROWTH

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