L‐NITROARGININE INCREASES BLOOD PRESSURE IN THE RAT
- 28 June 1991
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 18 (6) , 397-399
- https://doi.org/10.1111/j.1440-1681.1991.tb01470.x
Abstract
1. Effects of administration of NG-nitro-L-arginine (NO2Arg), a guanidino nitroarginine derivative, for 1 week on blood pressure and some vascular responses of rats were studied. 2. A significant rise of the systolic blood pressure was observed after the administration of NO2Arg with food (0.023% in weight, about 2.8 mg of NO2Arg per rat per day). Relaxation by acetylcholine decreased markedly in ring preparations of the thoracic aorta of NO2Arg-treated rats. However, glyceryltrinitrate-induced relaxation was not reduced after NO2Arg administration, suggesting that NO2Arg administration specifically inhibited endothelium-dependent relaxation. 3. An increase of blood pressure may be because oral administration of NO2Arg inhibited endothelium-dependent relaxation in vivo suggesting that the release of EDRF is important in physiological control of blood pressure.Keywords
This publication has 12 references indexed in Scilit:
- Indirect systolic and mean blood pressure determination by a new tail cuff method in spontaneously hypertensive ratsLaboratory Animals, 1991
- Nitroarginine inhibits endothelium-derived relaxation.The Japanese Journal of Pharmacology, 1990
- NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?Biochemical and Biophysical Research Communications, 1989
- L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxationBiochemical and Biophysical Research Communications, 1988
- INHIBITION OF VASODILATATION BY METHYLENE BLUE IN LARGE AND SMALL ARTERIES OF THE DOG HINDLIMB IN VIVOClinical and Experimental Pharmacology and Physiology, 1988
- Is arginine a physiological precursor of endothelium-derived nitric oxide?European Journal of Pharmacology, 1988
- Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.Circulation Research, 1987
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 1987
- The Role of Endothelium in the Responses of Vascular Smooth Muscle to DrugsAnnual Review of Pharmacology and Toxicology, 1984
- The Role of Endothelium in the Responses of Vascular Smooth Muscle to DrugsAnnual Review of Pharmacology and Toxicology, 1984