Correlation of Altered Q-T Interval and Sympathetic Nervous System Dysfunction in Diabetic Autonomic Neuropathy

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Abstract
We examined the relationship between the Q-T interval and autonomic dysfunction in 74 diabetic patients and age-matched controls. The expected Q-T interval was standardized as a function of the R-R interval in 646 healthy controls, and the Δ Q-T defined as the difference from the expected value. Propranolol increased Δ Q-T, confirming this as a parameter of autonomic function. No relationship between Δ Q-T and duration of disease, glucose control, retinopathy or proteinuria was observed. However, significant correlations were found between the Δ Q-T and delay of nerve conduction velocity, orthostatic hypotension, altered Valsalva ratio, abnormal Valsalva overshoot, cold pressor response, decreased norepinephrine concentration and sympathetic function score in diabetic patients.

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