THE INFLUENCE OF THE LIVER ON THE PROTEINS OF THE BLOOD PLASMA

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Abstract
During the period of circulatory readjustment immediately following complete removal of the liver some globulin appears to be added to the plasma. Somewhat similar amts. of globulin are added to the plasma of well fed control dogs during circulatory readjustments associated with plasmapheresis. The addition of globulin is diminished or absent in animals that have Eck''s fistulas or severely damaged livers when the protein content of the plasma was previously abnormal. The immediate changes of conc. of the plasma proteins after complete removal of the liver are a small loss, or dilution, of total protein with a similar change of the albumin content, a marked loss of fibrinogen and euglobulin and an increase of the pseudoglobulin of the plasma. In subsequent periods up to 30 hrs. after removal of the liver there is little evidence of loss or addition of protein to the plasma. In periods up to 9 hrs. after plasmapheresis in the liverless animal there is no evidence of regeneration of plasma proteins.

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