Penicillin in Experimental Spotted Fever

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Abstract
Male guinea pigs were injd. intraperit. with 1 ml. of a 10% suspension of spleens from guinea pigs infected with a virulent strain of spotted fever. They received 200 Oxf. units of penicillin intramusc. every 4 hrs. for 36 hrs. Injns. were begun 48 hrs. after the onset of fever. Controls were untreated or they received one dose of spotted fever rabbit immune globulin. Penicillin had no effect on the classic symptoms of this disease despite high plasma concs. of the drug. All treated animals died (penicillin toxicity in guinea pigs being a contributory factor). 8 out of 16 controls died. All animals receiving globulin survived.

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