Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
Open Access
- 1 December 2009
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 284 (50) , 35092-35100
- https://doi.org/10.1074/jbc.m109.022525
Abstract
No abstract availableKeywords
This publication has 57 references indexed in Scilit:
- Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1Journal of Virology, 2009
- Version 1.2 of the Crystallography and NMR systemNature Protocols, 2007
- Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase InhibitorsAntimicrobial Agents and Chemotherapy, 2007
- Site-directed Mutagenesis in the Fingers Subdomain of HIV-1 Reverse Transcriptase Reveals a Specific Role for the β3–β4 Hairpin Loop in dNTP SelectionJournal of Molecular Biology, 2006
- Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097Journal of Molecular Biology, 2006
- The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog MutationsJournal of Virology, 2006
- Stereo‐selectivity of HIV‐1 reverse transcriptase toward isomers of thymidine‐5′‐O‐1‐thiotriphosphateProtein Science, 2005
- Coot: model-building tools for molecular graphicsActa Crystallographica Section D-Biological Crystallography, 2004
- Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNAJournal of Biological Chemistry, 2003
- Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptaseJournal of Biological Chemistry, 2000