AUFTRETEN VON KASTRATIONSZELLEN IM HYPOPHYSENVORDERLAPPEN MÄNNLICHER RATTEN NACH BEHANDLUNG MIT EINEM ANTIANDROGEN

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Abstract
Following the administration of an androgen-antagonist (1,2α-methylene-6-chloro-pregna-4,6-diene-17α-ol-3,20-dione = cyproterone) to male rats, changes are observed in the anterior lobe of the pituitary gland comparable to those which develop following removal of the gonads. The appearance of so called castration cells is very striking, particularly in the periphery, and in the area adjacent to the pars intermedia. The findings suggest that the androgen-antagonism of cyproterone also manifests itself in those receptors of the sex centre, which regulate the amount of gonadotrophin production and secretion in relation to the production of testosterone. Since endogenous testosterone can no longer exert its inhibitory effect on the sex centre, the sex centre, as in a state of sexual hormone deficiency, reacts by secreting releasing factors for gonadotrophins. Thus those cell elements in the anterior lobe of the pituitary gland are stimulated and this leads to the production of gonadotrophin.

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