Isolation of human pancreastatin fragment containing the active sequence from a glucagonoma
Open Access
- 8 February 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 228 (1) , 153-156
- https://doi.org/10.1016/0014-5793(88)80606-9
Abstract
The primary structure of a human pancreastatin‐like peptide was determined from a pancreatic glucagonoma. The 28‐amino acid peptide was identified using a specific antibody raised against porcine pancreastatin 1–49 and showed a 75% sequence homology with porcine pancreastatin 22–49 and bovine chromogranin A 267–294. Several forms of pancreastatin‐like immunoreactivity were found in human endocrine tumors of which the purified peptide was the smallest and contained the active sequence of pancreastatin.Keywords
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