Operation of a DNA Robot Arm Inserted into a 2D DNA Crystalline Substrate
- 8 December 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 314 (5805) , 1583-1585
- https://doi.org/10.1126/science.1131372
Abstract
The success of nanorobotics requires the precise placement and subsequent operation of specific nanomechanical devices at particular locations. The structural programmability of DNA makes it a particularly attractive system for nanorobotics. We have developed a cassette that enables the placement of a robust, sequence-dependent DNA robot arm within a two-dimensional (2D) crystalline DNA array. The cassette contains the device, an attachment site, and a reporter of state. We used atomic force microscopy to demonstrate that the rotary device is fully functional after insertion. Thus, a nanomechanical device can operate within a fixed frame of reference.Keywords
This publication has 12 references indexed in Scilit:
- Design of Minimally Strained Nucleic Acid NanotubesBiophysical Journal, 2006
- Architecture with GIDEON, a program for design in structural DNA nanotechnologyJournal of Molecular Graphics and Modelling, 2006
- Folding DNA to create nanoscale shapes and patternsNature, 2006
- Translation of DNA Signals into Polymer Assembly InstructionsScience, 2004
- Nucleic acid nanostructures: bottom-up control of geometry on the nanoscaleReports on Progress in Physics, 2004
- Paranemic Crossover DNA: A Generalized Holliday Structure with Applications in NanotechnologyJournal of the American Chemical Society, 2004
- A robust DNA mechanical device controlled by hybridization topologyNature, 2002
- Construction, Analysis, Ligation, and Self-Assembly of DNA Triple Crossover ComplexesJournal of the American Chemical Society, 2000
- A DNA decamer with a sticky end: the crystal structure of d-CGACGATCGTJournal of Molecular Biology, 1997
- DNA double-crossover moleculesBiochemistry, 1993