Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir
- 1 August 1989
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 33 (8) , 1395-1399
- https://doi.org/10.1128/aac.33.8.1395
Abstract
Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.This publication has 36 references indexed in Scilit:
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