Androgen Control of Mitochondrial and Nuclear DNA Synthesis in Male Sex Accessory Tissue of Castrate Rats1

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Abstract
Incorporation of thymidine-3H methyl into nuclear and mitochondrial DNA was measured as a function of time and androgen or vehicle administration in male sex accessory tissue and liver of castrate rats. The activation of DNA synthesis by androgen is organ specific, i.e., noted only in seminal vesicle and prostate, but not in liver. The earliest activation noted occurred at 24 hr in seminal vesicle and at 48 hr in prostate and was sustained for up to 72 hr of androgenic stimulation. Increased nuclear and mitochondrial DNA synthesis occurred at the same time, suggesting that DNA is being synthesized in anticipation of the first wave of cell division, permitting nuclei and mitochondria to be replicated for parcelling out to daughter cells. Thus, neither nuclear nor mitochondrial DNA synthesis is required for the early action of androgen on its target tissues. (Endocrinology90: 1633, 1972)

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