The Role of Endogenous Opioids in Mediating Pain Reduction by Orally Administered Glucose Among Newborns
- 1 April 2005
- journal article
- clinical trial
- Published by American Academy of Pediatrics (AAP)
- Vol. 115 (4) , 1004-1007
- https://doi.org/10.1542/peds.2004-1189
Abstract
Objective. It has been demonstrated clearly that sweet-tasting solutions given before a painful intervention can reduce pain among newborns. There is no fully accepted explanation for this effect, but activation of endogenous opioids has been suggested as a possible mechanism. The aim of this study was to obtain deeper knowledge of the underlying mechanism by investigating whether administration of an opioid antagonist would reduce the effect of orally administered glucose at heel stick among term newborns.Keywords
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