CYCLIC 3',5'-ADENOSINE-MONOPHOSPHATE PHOSPHODIESTERASE IN THYMUS OF NORMAL AND LEUKEMIC MICE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 2  (6) , 417-425
Abstract
Changes in cyclic[c]AMP phosphodiesterase of the thymus were observed during leukemogenesis in the AKR mouse. On maturation, activity at 1.0 .mu.M and 100 .mu.M cAMP concentrations decreased in the AKR mouse and normal Swiss mice. The thymus of the leukemic mouse had sharply higher phosphodiesterase activity. Much of the phosphodiesterase activity of normal and leukemic mice was associated with particulate fractions, and, as indicated by marker enzymes for particulate components, the high affinity phosphodiesterase was enriched in a fraction containing plasma membranes.