The C3H/St/Ha Mammary Tumor. I. Thromboplastin Content2

Publisher Website
Google Scholar
Abstract
The thromboplastin activities of homogenates and extracts prepared from a mammary tumor in C3H/St/Ha mice, breast tissue from force-bred C3H siblings, and from T241 Lewis sarcoma were compared. There was more thromboplastin activity in the tumor homogenate of the C3H spontaneous mammary tumor than in the homogenate of “control” breast tissue. This greater activity of tumor tissue was more than could be accounted for by the greater amount of protein in the tumor tissue as compared to that in the breast tissue. Most of the tumor-homogenate thromboplastin activity was heat-stable. The activity of the homogenate of “control” breast tissue was almost completely heat-labile. Extracts of both the T241 sarcoma and the C3H mammary tumor contained heat-stable as well as a significant amount of heat-labile thromboplastin activity. The breast tissue from precancerous force-bred females showed very little extractable thromboplastin activity and just a trace of heat-labile activity.

This publication has 2 references indexed in Scilit: