Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo
- 1 December 1975
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 152 (3) , 709-712
- https://doi.org/10.1042/bj1520709
Abstract
The activity of a high-Km aldehyde dehydrogenase in the liver cytosol was increased by phenobarbital induction. No corresponding increase in the oxidation rate of acetaldehyde in vivo was found, and it is concluded that cytosolic aldehyde dehydrogenase plays only a minor role in the oxidation of acetaldehyde during ethanol metabolism.Keywords
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