Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes
- 1 September 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4051) , 793-795
- https://doi.org/10.1126/science.177.4051.793
Abstract
A new soluble mediator was found in supernatant fluid from cultures of human peripheral blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material present in human dental plaque deposits. This soluble Jactor produced bone resorption in organ cultures of fetal rat bones as measured by increased release of calcium-45, and also increased the number of active osteoclasts.Keywords
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