LUPINOSIS: RESPONSE OF SHEEP TO DIFFERENT DOSES OF PHOMOPSIN

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Abstract
Phomopsin, the mycotoxin produced by Phomopsis leptostromiformis, was found to have a very high toxicity for sheep. When administered as a single, subcutaneous injection over the dose range 125 to 98 g/kg body weight, all sheep given 375 g/kg or more died. Some, though not all, died following lower doses, the minimum lethal dose being 10 g/kg. The time course of hepatic response over 21 days after phomopsin administration was followed by plasma biochemical analyses including those for some enzymes (glutamate dehydrogenase, -glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase), total bilirubin and the determination of bromosulphophthalein clearance rates. Hepatobiliary impairment was apparent after all dosages of 25 g/kg and above while 125 g/kg approximated the 'no effect' level.