Synthesis of (.BETA.-methyl-3H)-benzylpenicillin and (.BETA.-methyl-3H)-6-aminopenicillanic acid.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (4) , 433-437
- https://doi.org/10.7164/antibiotics.29.433
Abstract
The synthesis of benzylpenicillin and 6-aminopenicillanic acid, labeled with 3H in the .beta.-methyl group, is described. Benzylpenicillin S-sulfoxide benzyl ester is refluxed in benzene and tritiated water and is successively debenzylated and deoxygenated to (.beta.-methyl-3H)-benzylpenicillin. Removal of the side chain with a bacterial acylase gives (.beta.-methyl-3H)-6-amino-penicillanic acid.This publication has 0 references indexed in Scilit: