The Effect of Certain Chemicals on Rickettsia Typhi Infections in Chick Embryos

Open Access
Publisher Website
Google Scholar
Abstract
Summary: Three hundred fifteen compounds were tested for rickettsiostatic activity against endemic typhus infections of chick embryos. Twenty-five of these substances significantly delayed death of the embryos. Several compounds related to para-aminobenzoic acid were effective; otherwise there was little correlation between rickettsiostasis and chemical structure. Penicillin fractions showed activity decreasing in the following order: penicillin X > dihydro-F > K > G. Cysteine inhibited the rickettsiostatic activity of penicillin G.
Keywords