Effects of Mezerein and Diglycerides on Ornithine Decarboxylase Activity in Mouse Mammary Gland Explants
- 1 April 1988
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 187 (4) , 432-434
- https://doi.org/10.3181/00379727-187-42684
Abstract
One of the most rapid actions of prolactin in mouse mammary gland explants is the stimulation of ornithine decarboxylase (ODC) activity. Several protein kinase C activators including mezerein, dicaprin, diolein,, and 1-oleoyl-2-acetyl-rac-glycerol were found to stimulate ODC activity as does prolactin. Both mezerein and the diglycerides produced nonadditive responses when tested with maximum stimulatory concentrations of prolactin. The results of these studies therefore provide further evidence that the prolactin stimulation of ODC activation in the mammary gland may involve an activation of protein kinase C.This publication has 2 references indexed in Scilit:
- Activation of protein kinase C by non-phorbol tumor promoter, mezereinBiochemical and Biophysical Research Communications, 1984
- Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotionProceedings of the National Academy of Sciences, 1980