Heterosexual Transmission of Human T Cell Leukemia/Lymphoma Virus Type I among Married Couples in Southwestern Japan: An Initial Report from the Miyazaki Cohort Study

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Abstract
To identify factors that may modify the heterosexual transmission of human T cell leukemia/lymphoma virus type 1 (HTLV-I), 534 married couples enrolled in the Miyazaki Cohort Study between November 1984 and April 1989 were studied: 95 husband HTLV-I-seropositive (H+)/wife seropositive (W+), 33 H+/W−, 64 H−/W+, and 342 H−/W−. After 5 years of follow-up, seven seroconversions occurred and clustered significantly among serodiscordant pairs (relative risk [RR] = 41.2); the rate oftransmission was 3.9 times higher if the carrier spouse was male (P = .19). Among H+/W− couples, husband's age ⩾60 years strongly predicted seroconversion in the WIves (RR = 11.5). All 4 carrier husbands whosewivesseroconverted had HTLV-I titers ⩾1:1024 (P = .04) and were anti-tax antibody positive (P = .06). In cross-sectional analysis, total parity also was independently associated with wife's serostatus but only length of marriage with husband's. Overall, sexual transmission of HTLV-I was primarily from older infected husbands to their wives, with husbands' viral status being an important factor.

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