Psoriasis After Allogeneic Bone Marrow Transplantation

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Abstract
To the Editor.— We describe the case of a 24-year-old woman, with a typical psoriasis that appeared 6 months after allogeneic bone marrow transplantation (BMT) from a psoriatic sibling HLA donor. Report of a Case.— In March 1986, a 24-year-old woman without psoriasis was admitted with mediastinal lymphoblastic non-Hodgkin's lymphoma. Between May and July 1986, three courses of an adriamycin-containing regimen induced complete remission. In September 1986, BMT was performed from an HLA-identical -A1, -A2, -B12, -B13, -DR7, -DRW6, negative, mixed lymphocyte culture brother with psoriasis, but no other disease. The young woman received cyclophosphamide plus fractionated total body irradiation as a conditioning regimen and graft-vs-host disease (GVHD) prophylaxis consisted of short doses of methotrexate (at days 1, 3, 6, and 11) and cyclosporine (4 mg/kg per day) intravenously, then orally twice daily. At day 62, a transient grade II acute GVHD of the skin appeared with a relapse on

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