Synthetic Applications of 2-(1,3-Dithian-2-yl)indoles. A New Synthetic Approach to Strychnos Alkaloids
- 1 January 1989
- journal article
- research article
- Published by CLOCKSS Archive in HETEROCYCLES
- Vol. 29 (11) , 2121-2133
- https://doi.org/10.3987/com-89-5114
Abstract
The first synthesis of Na-methyl-20-hydroxydasycarpidone 17b and the tetracyclic systems 16a and 16b are reported. The synthesis involves an acid cyclization of an appropriate 4-indolyl-carbonyl-2-piperidinecarbonitrile 15 which in turn is obtained regioselectively from the corresponding piperidinol 9 by a modified Polonovski reaction.Keywords
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