Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2
- 1 June 2007
- journal article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 18 (6) , 2137-2148
- https://doi.org/10.1091/mbc.e06-09-0850
Abstract
In this study, we investigated the molecular mechanisms underlying the ATP analogue adenosine-5′-O-(3-thio)triphosphate–induced nucleocytoplasmic shuttling of the mRNA stabilizing factor HuR in hum...Keywords
This publication has 41 references indexed in Scilit:
- Renovascular effects of sympathetic cotransmitters ATP and NPY are age-dependent in spontaneoulsy hypertensive ratsCardiovascular Research, 2005
- AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin α1Journal of Biological Chemistry, 2004
- ATP Potentiates Interleukin-1β-induced MMP-9 Expression in Mesangial Cells via Recruitment of the ELAV Protein HuRJournal of Biological Chemistry, 2003
- Ceramide induces translocation of protein kinase C-α to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domainBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2003
- Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 ExpressionJournal of Biological Chemistry, 2003
- Messenger-RNA-binding proteins and the messages they carryNature Reviews Molecular Cell Biology, 2002
- Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cellsJournal of Clinical Investigation, 2001
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Protein ligands mediate the CRM1-dependent export of HuR in response to heat shockRNA, 2001
- RNA stabilization by the AU-rich element binding protein, HuR, an ELAV proteinThe EMBO Journal, 1998