Destruction of Tumor Cells by BCG-Activated Alveolar Macrophages
Open Access
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (3) , 838-841
- https://doi.org/10.4049/jimmunol.119.3.838
Abstract
Alveolar macrophages obtained from Syrian golden hamsters were tested for their ability to destroy tumor cells. Only macrophages obtained from BCG immune animals rechallenged intratracheally with BCG five days before assay exhibited cytotoxic activity. Maximum destruction of tumor cells occurred after 5 days of incubation. Immunologic activation of macrophages was required to attain cytotoxic alveolar macrophages. Induction of inflammatory lung exudates by a variety of nonspecific irritants did not result in tumor cell destruction by macrophages. These observations may prove useful in designing an approach for immunotherapy of lung cancer.This publication has 0 references indexed in Scilit: